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. Author manuscript; available in PMC: 2021 Mar 26.
Published in final edited form as: Nat Methods. 2019 Jul 15;16(8):737–742. doi: 10.1038/s41592-019-0461-4

Figure 1: EPIC workflow.

Figure 1:

a) CF/MS experiments have three main steps: biochemical fractionation, MS analysis, and protein profile scoring. b) Automated computational analysis using EPIC takes CF/MS data as input and consists of three main steps: (i) calculation of co-elution profile similarity using correlation metrics; (ii) co-complex PPI scoring using machine learning-based integration of experimental and functional evidence; (iii) prediction, clustering, and benchmarking of derived complexes.