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Potency and cytotoxicity of mefloquine and 2,8-bis(trifluoromethyl)quinoline derivatives against ZIKV replication.
| Compound No. | EC50 (μM) | CC50 (μM) | SIa |
|---|---|---|---|
| Chloroquine | 12.0 ± 3.2 | 412 ± 24 | 34 |
| Mefloquine | 3.6 ± 0.3 | 212 ± 14 | 58 |
| 141a | 0.8 ± 0.06 | 195 ± 8.9 | 243 |
| 141b | 2.0 ± 0.1 | 287 ± 21 | 143 |
| 142 | 0.8 ± 0.03 | 189 ± 10 | 236 |
| 143 | 1.4 ± 0.09 | 316 ± 27 | 225 |
SI, selective index: determined as the ratio between CC50 and EC50.
