Table 10.

Anti-HIV-1 IIIB activity of compounds 333–350.

Compound No.	R	X	N	EC50 (μM)
333	H	Cl	1	50.61 ± 0.01
334	6-CH3	Cl	1	5.54 ± 0.01
335	6-OCH3	Cl	1	1.96 ± 0.004
336	7-CH3	Cl	1	0.72 ± 0.007
337	8-CH3	Cl	1	0.148 ± 0.006
338	H	Cl	2	2.92 ± 0.004
339	6-CH3	Cl	2	22.76 ± 0.002
340	6-OCH3	Cl	2	1.01 ± 0.01
341	7-CH3	Cl	2	2.55 ± 0.004
342	7-OCH3	Cl	2	0.46 ± 0.002
343	7-OCH(CH3)2	Cl	2	0.33 ± 0.001
344	8-CH3	Cl	2	0.50 ± 0.004
345	H	OCH3	1	1.41 ± 0.008
346	6-OCH3	OCH3	1	0.27 ± 0.003
347	H	OCH3	2	0.42 ± 0.002
348	6-OCH3	OCH3	2	1.51 ± 0.002
349	–	–	1	1.52 ± 0.004
350	–	–	2	1.93 ± 0.005
NB-64 (II)				2.4 ± 0.008