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Reported derivatives (145–152) screened against ZIKV.
| Compound No | EC50 (μM) | CC50 (μM) |
SI |
CC50 (μM) |
SI |
|---|---|---|---|---|---|
| SNB-19 | Vero cells | ||||
| 146 | 1.3 ± 0.1 | 22.7 ± 1.1 | 17.5 | 20.8 ± 0.5 | 16.1 |
| 150 | 11.0 ± 0.2 | 60.1 ± 1.1 | 5.5 | 22.8 ± 0.2 | 2.1 |
| 152 | 12.5 ± 0.4 | 67.7 ± 1.1 | 5.4 | 37.7 ± 0.1 | 3.0 |
| 154a | 8.5 ± 0.4 | 78.4 ± 1.0 | 9.2 | 55.9 ± 0.2 | 6.6 |
| 154b | 16.6 ± 0.3 | 66.5 ± 1.0 | 4.0 | 65.3 ± 0.3 | 3.9 |
