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Anti-Zika active derivatives of andrographolide.
| Compound No | EC50 (μM) | CC50 (μM) |
SI |
CC50 (μM) |
SI |
|---|---|---|---|---|---|
| SNB-19 | Vero cells | ||||
| 155a | 25.8 ± 1.1 | >100 | >3.9 | 99.8 ± 0.7 | 3.9 |
| 159a | 13.3 ± 0.5 | >100 | >7.5 | >100 | >7.5 |
| 159b | 7.8 ± 0.4 | 85.2 ± 1.0 | 10.9 | 82.5 ± 2.2 | 7.5 |
| 160b | 4.5 ± 0.2 | 88.7 ± 1.1 | 19.7 | 85.0 ± 1.6 | 18.9 |
| 161a | 24.6 ± 0.9 | 72.0 ± 1.0 | 2.9 | 57.4 ± 0.3 | 2.3 |
