Table 5.

SAR studies using different substitutions.

Compound No.	R1	R2	R3	R4	EC50 (μM)a
180	Cl	H	H	Ph	1.3
181	F	H	H	Ph	0.1
182	Br	H	H	Ph	3.1
183	OCF3	H	H	Ph	95.6
184	OCH3	H	H	Ph	2611
185	NO2	H	H	Ph	2.0
186	CF3	H	H	Ph	16.6
187	H	H	H	Ph	1.0
188	H	H	H	Ph	1.2
189	H	F	H	Ph	158.8
190	F	F	H	Ph	11.6
191	F	H	H	CH3	0.1
192	F	H	H	CH2CH3	6.4
193	F	H	H	(CH2)2CH3	19.0
194	F	H	H	(CH2)3CH3	2.1
195	F	H	H	CH2(C3H5)	6.8
196	F	H	H	CF3	1.0
197	F	H	H	4-Cl-Ph	2.0
198	F	H	H	4-NO2-Ph	4.9
199	F	H	H	3,4-(OCH2O)-Ph	0.9
200	F	H	H	2-F-Ph	0.3
201	F	H	H	3-F-Ph	0.1
202	F	H	H	4-F-Ph	1.0
203	F	H	H	2-pyridyl	22.9
204	F	H	H	3-pyridyl	2.5
205	F	H	H	2-thiazolyl	14.6

^aInhibition of VSV replication in MDCK epithelial cells.