Table 6.

Anti-RSV activity for the synthesized compounds.

Compound No.	R2	EC50 (μM)	CC50 (μM)
214		0.759	20.80
215	Ph	0.865	20.80
216	2-Cl-Ph	2.014	20.80
217	3-Cl-Ph	0.977	6.40
218	4-Cl-Ph	>100	6.60
219	COCH3	0.317	>100
220	COCH2CH3	3.090	>100
221	COCH(CH3)2	0.847	>100
222	COCH2CH(CH3)2	1.884	>100
223	CO(c-Hexyl)	9.240	>100
224	COPh	0.570	>100
225	COCH2Ph	0.079	>100
226	COCH2CH2Ph	0.464	>100
227	SO2CH3	2.272	>100
228	SO2Ph	1.166	20.50

^aEC₅₀: the concentration of compound that reduced 50% of the cytopathic effect of RSV. Long strain infected HEp-2 cells. CC₅₀: the concentration of compound that manifests cytotoxicity toward 50% of uninfected HEp-2 cells. Values are means of at least two experiments performed in consecutive weeks.