Table 7.

Anti-RSV activity for the synthesized compounds.

Compound No.	R1	R3	R4	R5	R6	EC50 (μM)	CC50 (μM)
229	H	H	2-Cl	H	H	0.077	>100
230	H	H	3-Cl	H	H	0.066	>100
231	H	H	4-Cl	H	H	0.058	>100
232	H	H	2-F	H	H	0.089	>100
233	H	H	3-F	H	H	0.080	>100
234	H	H	4-F	H	H	0.095	>100
235	H	H	2-CH3	H	H	0.029	>100
236	H	H	3-CH3	H	H	0.059	>100
237	H	H	4-CH3	H	H	0.142	>100
238	H	H	2-OCH3	H	H	0.056	>100
239	H	H	3-OCH3	H	H	0.098	>100
240	H	H	4-OCH3	H	H	0.679	>100
241	H	H	3-CN	H	H	0.225	>100
242	H	H	3-CF3	H	H	0.563	>100
243	H	H	3-F-4-F	H	H	0.255	>100
244	H	H	3-Cl-4-Cl	H	H	0.220	6.68
245	H	H	3-F-5-F	H	H	0.264	>100
246	H	NH2		CH3	H	0.759	20.80
247	H	NH2		Et	H	0.865	20.80
248	H	NH2		CH3	CH3	2.014	20.80
249	H	NH2		Et	Et	0.977	6.40
250	H	NH2		(CH2)2		>100	6.60
251	H	NH2		(CH2)3		0.317	>100
252	H	NH2		(CH2)4		3.090	>100
253	H	NHMe		CH3	CH3	0.847	>100
254	H	NMe2		CH3	CH3	1.884	>100
255	H	NHAc		CH3	CH3	9.240	>100
256	H	OH		CH3	CH3	0.570	>100
257	5-Cl	NH2		CH3	CH3	0.079	>100
258	6-Cl	NH2		CH3	CH3	0.464	>100
259	7-Cl	NH2		CH3	CH3	2.272	>100