Table 8.
hRSV CPE Assay potency, cytotoxicity, selectivity index, and logarithmic reduction in viral plaques for analogues with structural variation in the proline linker region of the hit sulfonylpyrrolidine scaffold.
| Compound No. |  |
EC50 (μM)a | CC50 (μM)b | SI | Virus titer log reduction |
|---|---|---|---|---|---|
| 260, ribavirin | NA | 28.4 ± 3.8 | 113.9 ± 38.5 | 4.0 | 2.5 |
| 261 |  |
5.0 ± 1.4 | 31.5 ± 5.7 | 6.3 | 2.1 |
| 262a |  |
>50 | 38.1 ± 2.3 | 0.8 | NT |
| 262b |  |
2.7 ± 0.9 | 31.8 ± 7.7 | 11.8 | 1.0 |
| 262c |  |
>50 | >50 | 1.0 | NT |
| 262d |  |
>50 | >50 | 1.0 | NT |
| 262e |  |
>50 | >50 | 1.0 | NT |
a
Data are an average of ≥3 experiments.
b
Data are an average of ≥2 experiments. cNT = not tested; NA = not applicable.