Table 1. Classification of EOC mouse models based on injection site.

Advantages	Disadvantages
Subcutaneous model
√ Easy to perform	√ Model is not physiologically relevant
√ Suitable for monitoring tumor growth	√ Absence of tumor microenvironment
√ Low variability in tumor size	√ Not suitable for studying angiogenesis
√ Good for routine evaluation of drug efficiency	√ Not suitable for studying tumor dissemination
√ Low cost
Intraperitoneal model
√ Easy to perform	√ Tumor growth measurements require advanced methods
√ Good model for studying late stages of EOC	√ Not suitable for studying early stages of EOC
√ Suitable for studying EOC dissemination	√ No primary tumor formation
√ Ascites formation	√ Not suitable for studying angiogenesis
√ Suitable for immunological studies
√ Low cost
Orthotopic model
√ Tumor microenvironment recapitulates physiological conditions	√ Difficult to perform
√ Suitable for studying all stages of disease	√ Tumor growth measurement requires advanced methods
√ Suitable for studying angiogenesis and tumor microenvironment	√ High cost
√ Suitable for immunological studies
√ Good model to study disease progression
√ Ascites formation