Table 2. Classification of EOC mouse models based on source of injected cells.

Advantages	Disadvantages
Established human EOC cell lines
√ Availability of cell lines	√ Cell alteration due to high number of passages
√ Large number of cell lines with various genetic backgrounds	√ Not suitable for immunological studies
√ Easy maintenance
√ Cells can be genetically manipulated
√ Low cost
Established mouse EOC cell lines
√ Availability of cell lines	√ Cell alteration due to high number of passages
√ Suitable for immunological studies
√ Easy maintenance
√ Cells can be genetically manipulated
√ Low cost
Patient-derived xenografts
√ PDX derived from EOC patients, not altered by in vitro culture	√ Slow tumor growth
√ Recapitulates EOC tumor microenvironment	√ Difficult maintenance
	√ Specialized training required
	√ Limited access to tumor samples
	√ PDXs cannot be genetically manipulated