Figure 4.

Pooled odds ratio for excellent outcome (mRS 0–1), good outcome (mRS 0–2) and better functional outcome (common OR across the whole range of the mRS) in patients with ischaemic stroke of 4.5–9 h duration (known onset time) treated with IVT vs. control. This analysis is restricted to the subgroup of patients enrolled in the EXTEND, ECASS 4 and EPITHET trials who meet the EXTEND mismatch criteria detected by automated software.

The numbers and the ORs for the 4.5–6 h and 6–9 h time windows (adjusted on age and baseline NIHSS score) are taken from the individual patient data meta-analysis by Campbell et al.