Table 7.
GRADE evidence profile for PICO 9.1.
| Certainty assessment |
No of patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | IVT with alteplase | no IVT | Relative(95% CI) | Absolute(95% CI) | ||
| mRS 0–1 at three months (six months in IST-3) | ||||||||||||
| 9 | randomised trials | not serious | not serious | seriousa | not serious | none | 237/345(68.7%) | 189/321(58.9%) | OR 1.48(1.07–2.06) | 91 more per 1 000(from 16 more to 158 more) | ⨁⨁⨁◯MODERATE | CRITICAL |
| Fatal ICH within seven days | ||||||||||||
| 9 | randomised trials | not serious | not serious | seriousa | very seriousb | strong association | 3/345(0.9%) | 0/321(0.0%) | OR 3.90(1.46–10.44) | 9 more per 1 000(from 4 more to 25 more) | ⨁⨁◯◯LOW | |
Note: All results are based on the individual patient data meta-analysis by Emberson et al.aThis result is based on an analysis of subgroups of patients included in RCTs with various inclusion criteria. There was no clear definition of disabling stroke in patients with NIHSS 0–4.bThe number of events was extremely low.