Table 3.
Investigation of possible predictors for duration of ventilation after cardiac surgery
| Variable | Category | Univariable model | Multivariable model | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | p valuej | OR | 95% CI | p valuej | ||
| Age [years]a | Linear | 1.03 | [1.02, 1.04] | < 0.001 | 1.01 | [1.00, 1.02] | 0.004 |
| Sexb | Male | 1 | [1.00, 1.00] | 0.066 | 1 | [1.00, 1.00] | 0.15 |
| Female | 1.16 | [0.99, 1.36] | 1.15 | [0.95, 1.38] | |||
| EF [%]c | ≤ 45 | 1 | [1.00, 1.00] | 0.015 | 1 | [1.00, 1.00] | 0.004 |
| 46–64 | 0.76 | [0.61, 0.95] | 1.02 | [0.80, 1.29] | |||
| ≥ 65 | 0.59 | [0.49, 0.71] | 0.77 | [0.62, 0.95] | |||
| EuroScored | 0–2 | 1 | [1.00, 1.00] | < 0.001 | 1 | [1.00, 1.00] | < 0.001 |
| 3–5 | 1.56 | [1.29, 1.88] | 1.29 | [1.03, 1.62] | |||
| > 6 | 3.05 | [2.50, 3.74] | 2.07 | [1.58, 2.72] | |||
| Creatinine [mg/dl]e | < 1.2 | 1 | [1.00, 1.00] | < 0.001 | 1 | [1.00, 1.00] | < 0.001 |
| 1.2–2.1 | 1.73 | [1.48, 2.04] | 1.54 | [1.29, 1.83] | |||
| > 2.1 | 2.99 | [1.93, 4.63] | 1.9 | [1.18, 3.05] | |||
| IL-6 [pg/ml]f | Q1 (< 102) | 1 | [1.00, 1.00] | 0.009 | 1 | [1.00, 1.00] | 0.003 |
| Q2 (102–165) | 1.01 | [0.80, 1.427] | 1.16 | [0.91, 1.49] | |||
| Q3 (166–256) | 1.16 | [0.92, 1.46] | 1.35 | [1.05, 1.73] | |||
| Q4 (257–421) | 1.11 | [0.88, 1.40] | 1.39 | [1.07, 1.80] | |||
| Q5 (> 421) | 1.45 | [1.16, 1.83] | 1.79 | [1.38, 2.32] | |||
| CPB [min]g | Q1 (< 72) | 1 | [1.00, 1.00] | < 0.001 | 1 | [1.00, 1.00] | < 0.001 |
| Q2 (72–85) | 1 | [0.80, 1.27] | 0.97 | [0.76, 1.24] | |||
| Q3 (86–100) | 1.04 | [0.82, 1.31] | 0.97 | [0.75, 1.24] | |||
| Q4 (101–124) | 1.16 | [0.92, 1.46] | 1.09 | [0.85, 1.40] | |||
| Q5 (> 124) | 1.83 | [1.45, 2.30] | 1.66 | [1.27, 2.16] | |||
| Operationh | CABG | 1 | [1.00, 1.00] | < 0.001 | 1 | [1.00, 1.00] | 0.53 |
| AV | 0.99 | [0.83, 1.018] | 1.01 | [0.83, 1.24] | |||
| CABG + AV | 1.43 | [1.13, 1.80] | 1.08 | [0.82, 1.43] | |||
| MV | 1.13 | [0.87, 1.47] | 1.08 | [0.80, 1.45] | |||
| MV + TV | 3.26 | [1.78, 5.97] | 1.78 | [0.91, 3.51] | |||
Logistic regression model investigating possible predictors for duration of ventilation after cardiac surgery. Baseline are patients with a ventilation time ≤ 12 h. The univariable model are shown in the left columns, the multivariable model adjusted to all variables listed above is presented in the right columns
aAge is analysed as linear variable
bThe reference category are males
cEjection fraction (EF) displayed in quintiles (resulting in 3 groups), reference category are values ≤ 45
dEuroScore analysed in three groups according to guidelines: mild/moderate/severe risk. The reference category is the lowest score
eCreatinine displayed in three groups. The reference category are lowest values
fIL-6 is displayed in Q (quintiles). The reference category is the first quintile
gCPB is displayed in Q (quintiles). The reference category is the first quintile
hReference category is CABG
jp value: from likelihood ratio test
OR odds ratio, CI confidence interval, EF ejection fraction, CPB cardiopulmonary bypass, CABG coronary artery bypass grafting, AV aortic valve surgery, CABG + AV combined operation of aortic valve and coronary artery bypass grafting, MV mitral valve surgery, MV + TV combined operation of mitral and tricuspid valve