TABLE 3.
The results of the explanatory multivariable logistic regression model showing risk factors associated with having stage B2 DMVD
| Variable | β | Odds ratio (95% CIs) | P |
|---|---|---|---|
| Intercept | −23.91 | 4.07 e−11 (4.59 e−16 ‐ 3.81 e−6) | <.001 |
| Age (≤8) | ‐ | ‐ | ‐ |
| Age (8‐10) | 0.34 | 1.41 (0.89‐2.24) | .15 |
| Age (10‐12) | −0.13 | 0.88 (0.54‐1.44) | .61 |
| Age (>12) | −0.47 | 0.63 (0.36‐1.10) | .11 |
| Appetite (Decreased) | 2.38 | 10.85 (2.60‐53.31) | .002 |
| Log10(ALT) | 7.45 | 1773.22 (3.32‐7.99 e5) | .02 |
| BCS (≤3) | ‐ | ‐ | ‐ |
| BCS (4) | −1.70 | 0.18 (0.06‐0.53) | .002 |
| BCS (5) | −1.32 | 0.27 (0.10‐0.74) | .01 |
| BCS (6) | −0.90 | 0.41 (0.15‐1.14) | .08 |
| BCS (7) | −1.69 | 0.19 (0.06‐0.58) | .004 |
| BCS (≥8) | −1.98 | 0.14 (0.03‐0.54) | .005 |
| Creatinine | −0.02 | 0.98 (0.97‐0.99) | <.001 |
| Murmur (soft) | ‐ | ‐ | ‐ |
| Murmur (moderate) | 0.94 | 2.57 (1.38‐5.09) | .004 |
| Murmur (loud) | 1.82 | 6.19 (3.37‐12.21) | <.001 |
| Murmur (thrilling) | 2.31 | 10.10 (4.81‐22.32) | <.001 |
| Log10(NT‐proBNP) | 7.77 | 2374.40 (49.23‐1.12 e5) | <.001 |
| Log10(ALT)*Log10(NT‐proBNP) | −2.25 | 0.10 (0.01‐0.89) | .04 |
Notes: For continuous variables, the odds ratio (OR) represents the change in odds associated with a 1‐unit increase in a variable according to its scale of measurement. This differs for logarithmically transformed variables where a 10‐fold change is used instead. For categorical variables, the OR represents the difference in odds when a category is compared to the reference group. Values of OR greater than 1 indicate that the odds of being in stage B2 increased with this variable. Values between 0 and 1 indicate that the odds reduced with this variable. Age was measured in years. ALT was measured in U/L. Creatinine underwent analysis in Systéme International (SI) units (μmol/L) so the coefficient reported reflects the change associated with a 1‐unit increase on this scale. ALT, alanine aminotransferase; BCS, body condition score; CI, confidence intervals; e, multiply by 10x; log10, logarithmic transformation to the base 10; NT‐proBNP, N‐terminal propeptide of B‐type natriuretic peptide; P, statistical significance; β, regression coefficient. A hyphen (‐) indicates that this category was used as a reference group for comparisons. The following levels of categorical variables were chosen as reference groups to provide a suitable point of comparison: age, ≤8 years; appetite, not reduced; BCS, ≤3; murmur intensity, soft.