TABLE 2.
Analyte‐specific unit and percentage annual change intervals
| Analyte | N | Annual change interval (analyte‐specific units) | Annual change interval (%) | ||||
|---|---|---|---|---|---|---|---|
| Median (range) | Lower limit (90% CI) | Upper limit (90% CI) | Median (range) | Lower limit (90% CI) | Upper limit (90% CI) | ||
| Albumin (g/dL) | 189/190* | 0.0 (−0.8, 0.6) | −0.4 (−0.8, −0.3) | 0.5 (0.3, 0.6) | 0 (−20, 18) | −11 (−20, −8) | 14 (10, 18) |
| ALP (U/L) | 188/190* | −3.0 (−43, 90) | −30 (−43, −20) | 19 (13, 90) | −13 (−61, 163) | −52 (−61, −48) | 74 (43, 163) |
| ALT (U/L) | 190/190 | −1 (−119, 170) | −46 (−102, −18) | 59 (22, 92) | −3 (−78, 271) | −60 (−70, −39) | 149 (67, 264) |
| Amylase (U/L) | 189/190* | −9 (−567, 1071) | −263 (−567, −217) | 397 (269, 1071) | −1 (−52, 179) | −39 (−52, −34) | 64 (44, 179) |
| AST (U/L) | 190/190 | 0 (−31, 26) | −19 (−27, −12) | 12 (10, 17) | 0 (−70, 123) | −47 (−55, −36) | 55 (50, 94) |
| BUN (mg/dL) | 190/190 | 0 (−12, 12) | −8 (−9, −7) | 6 (5, 8) | 0 (−50, 64) | −40 (−48, −33) | 49 (42, 58) |
| Calcium (mg/dL) | 189/190* | 0.0 (−1.8, 1.0) | −1.0 (−1.8, −0.8) | 0.7 (0.5, 1.0) | 0 (−18, 10) | −9 (−18, −7) | 7 (5, 10) |
| Chloride (mmol) | 189/190* | 0 (−7, 7) | −4 (−7, −4) | 5 (3, 7) | 0 (−6, 6) | −4 (−6, −3) | 5 (3, 6) |
| Cholesterol (mg/dL) | 189/190* | 7 (−157, 166) | −86 (−157, −75) | 95 (88, 166) | 3 (−36, 83) | −30 (−36, −25) | 43 (33, 83) |
| Creatine kinase (U/L) | 190/190 | −1.5 (−438, 259) | −156 (−393, −92) | 137 (97, 244) | −1.4 (−91, 323) | −73 (−82, −61) | 179 (108, 213) |
| Creatinine (mg/dL) | 190/190 | 0.0 (−1.3, 0.3) | −0.3 (−1.2, −0.2) | 0.3 (0.2, 0.3) | 0 (−100, 43) | −28 (−100, −21) | 28 (22, 33) |
| GGT (U/L) | 190/190 | 0 (−9, 8) | −5 (−7, −3) | 6 (4, 7) | 0 (−83, 600) | −66 (−80, −50) | 323 (150, 500) |
| Globulin (g/dL) | 189/190* | 0.1 (−0.7, 0.9) | −0.5 (−0.7, −0.4) | 0.8 (0.6, 0.9) | 4 (−23, 45) | −16 (−23, −12) | 34 (27, 45) |
| Glucose (mg/dL) | 189/190* | −2 (−36, 41) | −26 (−36, −20) | 25 (17, 40) | −2 (−38, 84) | −26 (−38, −20) | 32 (21, 84) |
| Lipase (U/L) | 82/190* | 12 (−314, 349) | −190 (−225, −145)^ | 214 (170, 251)^ | 5 (−68, 306) | −46 (−52, −38)^ | 128 (87, 292)^ |
| Magnesium (mg/dL) | 189/190* | 0.0 (−0.3, 1.0) | −0.2 (−0.3, −0.1) | 0.3 (0.2, 1.0) | 0 (−16, 67) | −11 (−16, −7) | 22 (14, 67) |
| Potassium (mmol) | 189/190* | 0 (−0.8, 0.9) | −0.6 (−0.8, −0.5) | 0.5 (0.4, 0.9) | 0 (−16, 22) | −14 (−16, −11) | 13 (9, 22) |
| Phosphate (mg/dL) | 189/190* | −0.3 (−2.2, 2.8) | −1.9 (−2.2, −1.5) | 1.3 (0.7, 2.8) | −7 (−38, 76) | −36 (−38, −33) | 41 (23, 76) |
| Sodium (mmol) | 189/190* | 0 (−5, 9) | −4 (−5, −3) | 4 (4, 9) | 0 (−3, 6) | −3 (−3, −2) | 3 (3, 6) |
| Total bilirubin (mg/dL) | 189/190* | 0 (−0.2, 0.2) | −0.1 (−0.2, −0.1) | 0.1 (0.1, 0.2) | 0 (−67, 200) | −50 (−67, −33) | 100 (100, 200) |
| Total protein (g/dL) | 189/190* | 0.1 (−0.8, 1.2) | −0.6 (−0.8, −0.4) | 0.9 (0.7, 1.2) | 2 (−12, 21) | −9 (−12, −6) | 16 (12, 21) |
| Total T4 (μg/dL) | 190/190 | 0 (−1.6, 2.4) | −1.1 (−1.3, −0.9) | 1.3 (1.0, 1.6) | 0 (−88, 200) | −53 (−62, −47) | 126 (82, 185) |
| Triglycerides (mg/dL) | 189/190* | 1 (−227, 126) | −60 (−227, −24) | 80 (60, 126) | 2 (−79, 286) | −50 (−79, −36) | 183 (129, 286) |
Note: Annual changes were calculated by subtracting the result for year 2 from the result for year 1, so positive changes are an increase and negative changes a decrease in analyte concentrations between annual health checks. * indicates data missing from at least one reference individual. Reasons for missing data could not be retrieved for individual dogs; ^ indicates calculation using the robust method with 90% CI after Box‐Cox transformation. CI, confidence interval.