TABLE 2.
Clinical and echocardiographic data determined on D0 (FAS population)
| Pimobendan (n = 39) | Placebo (n = 37) | |
|---|---|---|
| HR (min−1) | 196 ± 28 | 202 ± 24 |
| RR (min−1) | 43 ± 18 | 50 ± 23 |
| LVOTO a | 14 (36%) | 15 (41%) |
| LAD (mm) | 19.50 ± 3.70 | 20.10 ± 4.16 |
| IVSd (mm) | 6.40 ± 1.34 | 6.90 ± 1.10 |
| LVFWd (mm) | 7.30 ± 1.29 | 7.40 ± 1.63 |
| LVIDd (mm) | 14.80 ± 2.67 | 14.20 ± 2.58 |
| LVIDs (mm) | 8.0 ± 2.59 | 7.40 ± 2.03 |
| SF (%) | 47 ± 11 | 47 ± 11 |
| S′ (cm/s) | 4.7 ± 2.0 | 4.9 ± 1.4 |
| IVRT (ms) | 47 ± 11 | 47 ± 17 |
| E (m/s) | 0.90 ± 0.37 | 0.90 ± 0.36 |
| E:A | 1.60 ± 0.78 | 2.10 ± 1.12 |
| E′ (cm/s) | 5.0 ± 2.26 | 6.1 ± 2.65 |
| E:E′ | 19.2 ± 10.4 | 17.5 ± 10.2 |
| LV diastolic function | ||
| Normal | 1 (3%) | 2 (5%) |
| Abnormal | 28 (72%) | 31 (84%) |
| Class 2 and 3 | 10 (26%) | 7 (19%) |
| Class 4 and 5 | 18 (46%) | 24 (65%) |
| Not evaluated b | 10 (25%) | 4 (11%) |
Abbreviations: Class 4 and 5, “pseudonormal” and “restrictive” left ventricular filling; d, measured at end‐diastole; E, peak velocity of early transmitral flow; E:A, ratio between E and peak velocity of late transmitral flow velocity (A); E:E′, ratio between E and E′; E′, peak velocity of the lateral mitral annulus measured by tissue Doppler imaging in early diastole; HR, heart rate; IVRT, isovolumic relaxation time; IVS, dimension of the interventricular septum; LAD, maximum left atrial cranial‐caudal dimension measured parallel to the mitral valve plane; LVFW, dimension of the left ventricular free wall; LVID, left ventricular dimension; LVOT, left ventricular outflow tract obstruction; RR, respiratory rate; s, measured at end‐systole; S′, peak velocity of the lateral mitral annulus measured by tissue Doppler imaging in systole; SF, left ventricular shortening fraction.
Determined by continuous wave Doppler echocardiography and defined as systolic pressure gradient across the LVOT ≥30 mm Hg.
Because of missing data or fusion of filling waves; Absolute and relative frequencies as well as means and standard deviations are presented. There was no difference between treatment groups for any variable (all P > .05).