FIGURE 3.

Effect of the ubiquitin‐specific protease 7 (USP7) inhibition on the induction of apoptosis. Results of annexin V/propidium iodide (PI) staining after treatment for 24 and 48 hours with P5091 for canine lymphocytes obtained from healthy donors (n = 4), A, with representative dotplots, B. Analysis as in A, but for CLBL‐1, CLB70, CNK‐89 and GL‐1 cell lines after 24 hours, C, and 48 hours, E, of treatment with P5091, with representative dotplots, D, F, respectively. For each cells, values without common letters (a, b, c) in the superscript differ statistically (P < .05)