TABLE 3.
Linear mixed model analysis of changes in variables after introduction of Royal Canin Senior Consult Stage 2 diet showing (A) cats with ionized hypercalcemia at diagnosis of azotemic CKD (BHCa group, n = 11) and (B) cats that developed ionized hypercalcemia after being diagnosed with azotemic CKD (RDHCa group, n = 10). Quadratic terms for time (time2) were included in initial models to account for potential nonlinear changes of variables over time, and subsequently removed if not significant
| (A) | β (month) | SE | 95% CI | P‐value | β (month2) | SE | 95% CI | P‐value |
|---|---|---|---|---|---|---|---|---|
| Ionized calcium (mmol/L) | 0.006 | 0.005 | −0.003 to 0.015 | .18 | ||||
| Total calcium (mg/dL) | 0.014 | 0.044 | −0.080 to 0.099 | .75 | ||||
| ln PTH (pg/mL) | 0.002 | 0.010 | −0.018 to 0.022 | .81 | ||||
| ln Phosphate (mg/dL) | −0.064 | 0.026 | −0.116 to (−0.014) | .02 | 0.006 | 0.003 | 0.001‐0.011 | .04 |
| Ca × P (mg2/dL2) | −0.186 | 0.382 | −0.988 to 0.560 | .63 | ||||
| ln Creatinine (mg/dL) | −0.013 | 0.006 | −0.026 to (−0.001) | .04 | ||||
| ln FGF23 (pg/mL) | −0.035 | 0.022 | −0.081 to 0.009 | .13 | ||||
| Potassium (mmol/L) | −0.120 | 0.035 | −0.187 to (−0.050) | <.01 | 0.011 | 0.003 | 0.004‐0.017 | <.01 |
| Sodium (mmol/L) | −0.039 | 0.066 | −0.168 to 0.094 | .56 | ||||
| Albumin (g/dL) | 0.007 | 0.004 | −0.001 to 0.014 | .11 | ||||
| Total protein (g/dL) | 0.011 | 0.012 | −0.013 to 0.034 | .37 | ||||
| HCO3‐ (mEq/L) | −0.181 | 0.072 | −0.325 to (−0.039) | .02 | ||||
| pH | −0.002 | 0.001 | −0.004 to 0.000 | .1 | ||||
| Body weight (kg) | −0.015 | 0.005 | −0.025 to (−0.005) | <.01 |
| (B) | β (month) | SE | 95% CI | P‐value | β (month2) | SE | 95% CI | P‐value |
|---|---|---|---|---|---|---|---|---|
| Ionized calcium (mmol/L) | −0.056 | 0.013 | −0.081 to (−0.030) | <.01 | ||||
| Total calcium (mg/dL) | −1.133 | 0.204 | −1.524 to (−0.719) | <.01 | 0.158 | 0.042 | 0.073‐0.239 | <.01 |
| ln PTH (pg/mL) | 0.322 | 0.078 | 0.147 to 0.476 | <.01 | ||||
| ln phosphate (mg/dL) | −0.026 | 0.023 | −0.072 to 0.022 | .29 | ||||
| Ca × P (mg2/dL2) | −2.83 | 1.18 | −5.21 to (−0.398) 0.019 | .03 | ||||
| ln Creatinine (mg/dL) | −0.003 | 0.016 | −0.035 to 0.029 | .87 | ||||
| ln FGF23 (pg/mL) | −0.167 | 0.118 | −0.407 to 0.072 | .19 | ||||
| Potassium (mmol/L) | −0.045 | 0.023 | −0.089 to 0.003 | .07 | ||||
| Sodium (mmol/L) | 0.040 | 0.186 | −0.345 to 0.042 | .83 | ||||
| Albumin (g/dL) | 0.008 | 0.016 | −0.025 to 0.042 | .65 | ||||
| Total protein (g/dL) | 0.001 | 0.036 | −0.076 to 0.071 | .98 | ||||
| HCO3 − (mEq/L) | −0.205 | 0.189 | −0.576 to 0.197 | .31 | ||||
| pH | −0.005 | 0.005 | −0.013 to 0.004 | .31 | ||||
| Body weight (kg) | −0.018 | 0.025 | −0.068 to 0.034 | .5 |