Table 2.

Toxicity of the most commonly used chemicals in solvent‐based clearing.

Name of the chemical	Method	Safety level	Information
Benzyl Alcohol Benzyl Benzoate	BABB, FluorClearBABB, uDISCO, vDISCO, fDISCO, sDISCO, SHANEL	Mild precaution required	Both chemicals are commonly used in cosmetics
Tetrahydroflurane (THF)	3DISCO, iDISCO, vDISCO, sDISCO	Moderate precaution required	Avoid inhalation of the vapor, might cause nausea, dizziness, headache…
Dibenzyl Ether (DBE)	DBE, eDISCO, fDISCO, sDISCO	Mild precaution required	Commonly used food additive, no harmful effect
Ethyl Cinnamate (ECi)	ECi, BALANCE, EyeCi	Safe	Ethyl cinnamate is an FDA‐approved food flavor and additive to cosmetic products
Tertiary Butanol	uDISCO, PEGASOS	Moderate precaution required	Vapor is narcotic and irritating in action. Liquid is irritating to skin and eyes
Dichloromethane (DCM)	3DISCO, iDISCO uDISCO, vDISCO, SHANEL	Moderate precaution required	As an artificial compound, it irritates the skin and eyes
N,N,N′,N′‐Tetrakis(2‐hydroxypropyl) ethylenediamine (Quadrol)	vDISCO, PEGASOS	Severe precaution required	Quadrol can cause skin irritation, serious eye damage and serious eye irritation
Ethylenediaminetetraacetic acid (EDTA)	vDISCO, PEGASOS	Safe	EDTA is a safe compound to use; it only irritates the eyes, skin, and respiratory tract in high exposures
Methanol	iDISCO, SHANEL	Moderate precaution required	High concentrations can produce central nervous system depression and optic nerve damage. Can be absorbed through the skin