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. 2020 Dec 25;20:634–645. doi: 10.1016/j.omto.2020.12.010

Figure 3.

Figure 3

lncRNA SNHG4 mediates H1299 cell proliferation, migration, invasion, and apoptosis by binding with miR-let-7e

(A) Expression of lncRNA SNHG4 and miR-let-7e after knockdown of lncRNA SNHG4 in H1299 cells. (B) H1299 cell viability measured by CCK-8 assays. (C) Numbers of colonies derived from H1299 cells. (D) Scratch wound healing. (E) H1299 cells invading from Matrigel-coated upper transwell chambers into lower ones. (F) H1299 cell apoptosis determined by annexin V/PI-labeled flow cytometric analysis. (G) Western blots and quantification of caspase-3 and cleaved caspase-3 in H1299 cells, normalized to β-actin expression. ∗p < 0.05 (compared with H1299 cells treated with scramble siRNA alone and/or inhibitor NC), #p < 0.05 (compared with H1299 cells treated with oe-NC alone or lncRNA SNHG4-specific siRNA plus inhibitor NC), and &p < 0.05 (compared with H1299 cells treated with oe-NC alone) by Tukey’s test-corrected one-way ANOVA or Bonferroni-corrected repeated-measures ANOVA.