TABLE 6.
Summary of the acute toxicity study with ω‐imidazolyl‐alkyl derivatives
| Toxicological parameters | I‐ol | I‐an |
|---|---|---|
| No Observed Adverse Effect Level | 500 | 250 |
| (mg/kg bw) | ||
| No‐Observed‐Effect Level | 1000 | 500 |
| (mg/kg bw) | ||
| Lowest lethal dose | >1000 | 500 |
| (mg/kg bw) | ||
| LD50(14 d) | >1000 | >1000 |
| (mg/kg bw) | ||
| Toxic signs | ||
| 250 mg/kg bw | None | None |
| 500 mg/kg bw | None | Mortality |
| 1000 mg/kg bw | Reduced motility and muscle tone, ataxia, dyspnoea | Mortality |
| Macroscopic necropsy findings | None | None |
+ = slight/observed
++ = moderate
In brackets: Number of animals affected