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. 2021 Mar 25;9:55. doi: 10.1186/s40478-021-01132-7

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© The Author(s) 2021

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Fig. 3 — PrP immunohistochemistry (IHC). a: Cerebral cortex. 1st row, VV1: PrP granular deposits (arrowheads) often distributed around the rim of vacuoles. VV2: A plaque-like PrP. 2nd row, VV1²⁰: PrP deposits co-distributing with SD; arrowhead: granular PrP. VV1²¹ and VV1²¹⁻²⁰*: negative PrP IHC. VV2: A PrP plaque; inset: H.E. staining of the plaque. b: Cerebellum. 1st row, VV1²⁰ and VV1²¹⁻²⁰*: PrP deposition affecting the granule cell layer (grl. L.); arrowhead, VV1²¹⁻²⁰*: granular PrP. VV1²¹ and VV2: Negative PrP IHC; mol. L.: molecular layer. 2nd row, VV1²⁰: PrP deposition in grl. L. VV1²¹ and VV1²¹⁻²⁰*: Negative PrP IHC. VV2: Plaque and plaque-like PrP ; dotted and dashed insets: two PrP plaques depicted on H.E. and IHC preparations, respectively. Scale bar insets: 20 µm; Ab: 3F4