Figure 1.

Gpr52^-/- mice exhibit leanness associated with increased insulin sensitivity

(A) Changes in body weight of Gpr52^-/- and WT mice (n = 5).

(B) Tissue weight of Gpr52^-/- and WT mice (n = 7, 19 weeks old).

(C) OGTT (2 g/kg) in Gpr52^-/- and WT mice. Plasma glucose (left) and insulin (right) concentrations are plotted at the indicated time points (n = 5, 17 weeks old).

(D) Representative western blot analysis of p-Akt (S473) level (upper), Akt (middle), and α-tubulin (lower) of epiWAT (left) and liver (right). The ratio of p-Akt (S473) level to Akt was quantified in the graphs.

Data are means ± SEM. ∗p <0.05, ∗∗p < 0.01, between the animal groups by unpaired Student’s t test. See also Figure S1.