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. 2021 Mar 2;24(4):102260. doi: 10.1016/j.isci.2021.102260

Figure 2.

Figure 2

Gene expressions of the enzymes involved in biosynthesis of fatty acid and cholesterol were altered in metabolic tissues of Gpr52-/- mice

(A) GPR52 mRNA expression in various human tissues and HepG2 cells.

(B) Gpr52 mRNA expression in the brain, epiWAT, liver, skeletal muscle, and pancreatic islets of mice. (A and B) Expression levels are shown as relative values normalized to GAPDH (A) or Gapdh (B) (n = 3–4). The expressions in the brain are represented as 1.

(C) Gpr52 mRNA expression in the adipocyte and SVF in mice. Adiponectin (Adipoq) and F4/80 (Adgre1) are indicated as markers of adipocyte and SVF, respectively (n = 4).

(D) Gene expressions of the enzymes involved in fatty acid biosynthesis (Scd1, Elovl6, Acc1, Acc2, Dgat2, and Acss2) and cholesterol biosynthesis (Hmgcr) in metabolic tissues (ingWAT, epiWAT, BAT, and liver) of Gpr52-/- and WT mice under fed condition (n = 5, 19 weeks old). Data are means ± SEM. ∗p <0.05, ∗∗p < 0.01, between the animal groups by unpaired Student’s t test.