Figure 3.

Topological analysis of downregulated membrane proteins and positional analysis of the cleavage sites

(A) Percentages of the various topologies of membrane proteins identified with downregulated cleavage sites. The categories of membrane proteins follow the notation in UniProt.

(B) The distribution of the distance (number of amino acids) from the transmembrane domain or GPI-anchor site to the cleavage site is depicted for single-pass type-I and type-II membrane proteins and GPI-anchored proteins. The section surrounded with a red box is shown in detail above. TM: cleavage sites within the transmembrane domain. Cyto: cleavage sites within the cytoplasmic domain.

(C) Relative cleavage positions of the cleavage sites within the transmembrane domain of single-pass type I and type II membrane proteins. Values represent the length (number of amino acids) from the extracellular region to the cleavage site, divided by the total length (number of amino acids) of the transmembrane domain.