Table 2.
Single channel parameters measured for five GlyRs
| Single-channel parameters | |||||
|---|---|---|---|---|---|
| GlyR | Glycine | β-Alanine | Taurine | GABA | Amplitude (pA) |
| Human α1 GlyR | |||||
| maxPopen | 0.97 ± 0.11 | 0.78 ± 0.24 | 0.46 ± 0.20 | 0.09 ± 0.08 | 5.96 ± 0.70 |
| npatches (nclusters) | 5 (47) | 5 (124) | 11 (144) | 13 (59) | |
| Zebrafishα1 GlyR | |||||
| maxPopen | 0.97 ± 0.05 | 0.91 ± 0.21 | 0.66 ± 0.24 | 0.40 ± 0.25 | 5.45 ± 0.92 |
| npatches (nclusters) | 10 (48) | 7 (30) | 10 (71) | 11 (83) | |
| Human a1 GlyR ΔICD | |||||
| maxPopen | 0.99 ± 0.01 | 0.92 ± 0.07 | 0.90 ± 0.10 | 0.70 ± 0.21 | 4.11 ± 0.72 |
| npatches (nclusters) | 5 (26) | 6 (26) | 10 (33) | 4 (37) | |
| Human α1 GlyR ΔICD + TM4 zebrafish | |||||
| maxPopen | 0.98 ± 0.02 | 0.88 ± 0.16 | 0.89 ± 0.12 | 0.73 ± 0.24 | 3.63 ± 0.88 |
| npatches (nclusters) | 4 (16) | 7 (29) | 6 (41) | 4 (43) | |
| Zebrafish α1 GlyR ΔICD | |||||
| maxPopen | 0.99 ± 0.02 | 0.98 ± 0.05 | 0.93 ± 0.13 | 0.89 ± 0.13 | 4.74 ± 1.10 |
| npatches (nclusters) | 5 (32) | 9 (25) | 7 (26) | 5 (23) | |
| Zebrafishα1 GlyREM | |||||
| maxPopen | 0.98 ± 0.02 | 0.97 ± 0.08 | 0.95 ± 0.10 | 0.90 ± 0.14 | 5.54 ± 1.59 |
| npatches (nclusters) | 10 (42) | 9 (54) | 17 (55) | 7 (77) | |
The values are presented as mean ± S.D.