Table II.
Composition of the Different Liposomal Batches
| Formulation No. | Composition | |||||
|---|---|---|---|---|---|---|
| F1 | HSPC | DSPE-PEG-2000 | CHO | |||
| F2 | HSPC | DSPE-PEG-2000 | Mal-PEG-2000 | DOPE | DOTAP | |
| F3 | HSPC | DSPE-PEG-2000 | Mal-PEG-2000 | DOPE | DDAB | |
| F4 | POPC | DSPE-PEG-2000 | CHO | |||
| F5 | POPC | DSPE-PEG-2000 | Mal-PEG-2000 | DOPE | DOTAP | |
| F6 | POPC | DSPE-PEG-2000 | Mal-PEG-2000 | DOPE | DDAB | |
| F7 | DOPC | DSPE-PEG-2000 | CHO | |||
| F8 | DOPC | DSPE-PEG-2000 | Mal-PEG-2000 | DOPE | DOTAP | |
| F9 | DOPC | DSPE-PEG-2000 | Mal-PEG-2000 | DOPE | DDAB | |
| F10 | DPPC | DSPE-PEG-2000 | CHO | |||
| F11 | DPPC | DSPE-PEG-2000 | Mal-PEG-2000 | DOPE | DOTAP | |
| F12 | DPPC | DSPE-PEG-2000 | Mal-PEG-2000 | DOPE | DDAB |
HSPC, L-α-phosphatidylcholine, hydrogenated (Soy); POPC, 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine; DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine; DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DSPE-PEG-2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt); Mal-PEG-2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (ammonium salt); CHO, cholesterol; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; DOTAP, 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt); DDAB, dimethyldidodecylammonium bromide