Fig. 1.

ALDH2 knockout increases cholesterol levels in mouse serum and liver even with chow diet feeding. (A) Mouse weights increased in AKO mice compared to WT at 12^th week (chow diet, n = 10). (B) Representative H&E and oil red staining for liver, Scale bar: 400 μm. (C) Triglycerides (TG) in WT and AKO mouse serum at 12^th week (chow diet, n = 10). (D) Total cholesterol in serum (chow diet, n = 10) and (E) liver of 12^th week mice (chow diet, n = 5). (F–G) Total cholesterol and LDL-C in WT and AKO mouse serum from 5 to 28-week old (chow diet, n = 10). Statistical comparisons were made using a 2-tailed Student's t-test. All data are mean ± SD. *P < 0.05, **P < 0.01, WT: wild type; AKO: ALDH2 Knockout; ALDH2^+/−, heterozygous; ALDH2^−/−, homozygous. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)