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. 2021 Mar 10;41:101919. doi: 10.1016/j.redox.2021.101919

Fig. 8.

Fig. 8

Lovastatin inhibits the increased cholesterol levels in ALDH2 KO and rs671 mouse serum and liver. A-D. Total cholesterol and LDL-C in rs671 (A) and AKO (B) mouse serum; LDL-C levels in rs671 (C) and AKO (D) mouse serum. (E–F) Lovastatin treatment diminished lipid accumulation in ALDH2 2*2 and ALDH2 KO mouse liver (n = 10). (G–H) LC-MS analysis of major intermediates in cholesterol synthesis in rs 671 and AKO mouse liver (n = 5). (I–J) GC-MS analysis of lanosterol and total cholesterol in mice liver (n = 5). Statistical comparisons were made using an ANOVA. All data are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. WT: wild type; AKO: ALDH2 Knockout.