Table 3.
Association between fulminant NEC and hematological measures using multinomial logistic regression.
| Unadjusted models | Adjusted models | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Difference | β | OR | p value | 95% CI | β | OR | p value | 95% CI | ||
| Δ Absolute neutrophil count | ||||||||||
| Δ ANC before and day of NEC | 0.07 | 1.07 | 0.04 | 1.003 | 1.14 | 0.07 | 1.07 | 0.04 | 1.003 | 1.14 |
| Δ ANC before and 24 h NEC | 0.05 | 1.05 | 0.29 | 0.96 | 1.15 | 0.05 | 1.05 | 0.27 | 0.96 | 1.15 |
| Δ ANC before and 48 h NEC | 0.08 | 1.09 | 0.09 | 0.99 | 1.20 | 0.10 | 1.10 | 0.07 | 0.99 | 1.22 |
| Absolute lymphocyte count | ||||||||||
| Δ ALC before and day of NEC | −0.03 | 0.97 | 0.73 | 0.81 | 1.16 | −0.04 | 0.96 | 0.68 | 0.80 | 1.16 |
| Δ ALC before and 24 h NEC | 0.14 | 1.15 | 0.29 | 0.89 | 1.47 | 0.14 | 1.15 | 0.29 | 0.89 | 1.48 |
| Δ ANC before and 48 h NEC | 0.24 | 1.27 | 0.19 | 0.89 | 1.82 | 0.25 | 1.29 | 0.18 | 0.89 | 1.86 |
| Platelet count | ||||||||||
| Δ Platelet before and day of NEC | 0.01 | 1.01 | 0.01 | 1.001 | 1.01 | 0.004 | 1.00 | 0.02 | 1.001 | 1.01 |
| Δ Platelet before and 24 h NEC | 0.01 | 1.01 | 0.03 | 1.001 | 1.01 | 0.01 | 1.01 | 0.05 | 1.000 | 1.01 |
| Δ Platelet before and 48 h NEC | 0.01 | 1.01 | 0.11 | 1.00 | 1.01 | 0.01 | 1.01 | 0.14 | 0.99 | 1.01 |
| Absolute monocytes count | ||||||||||
| Δ AMC before and day of NEC | 0.17 | 1.18 | 0.2 | 0.92 | 1.52 | 0.18 | 1.19 | 0.17 | 0.93 | 1.53 |
| Δ AMC before and 24 h NEC | 0.12 | 1.12 | 0.46 | 0.82 | 1.53 | 0.13 | 1.14 | 0.43 | 0.83 | 1.57 |
| Δ AMC before and 48 h NEC | 0.24 | 1.27 | 0.22 | 0.87 | 1.84 | 0.26 | 1.29 | 0.20 | 0.87 | 1.91 |
| WBC count | ||||||||||
| Δ WBC before and day of NEC | 0.03 | 1.03 | 0.13 | 0.99 | 1.08 | 0.03 | 1.03 | 0.14 | 0.99 | 1.08 |
| Δ WBC before and 24 h NEC | 0.05 | 1.05 | 0.12 | 0.99 | 1.11 | 0.05 | 1.05 | 0.09 | 0.99 | 1.12 |
| Δ WBC before and 48 h NEC | 0.06 | 1.06 | 0.04 | 1.003 | 1.12 | 0.06 | 1.07 | 0.03 | 1.01 | 1.13 |
| Eosinophil count | ||||||||||
| Δ AEC before and day of NEC | −0.002 | 1.00 | 0.98 | 0.86 | 1.16 | −0.02 | 0.99 | 0.85 | 0.84 | 1.16 |
| Δ AEC before and 24 h NEC | −0.02 | 0.98 | 0.77 | 0.84 | 1.14 | −0.03 | 0.98 | 0.74 | 0.84 | 1.13 |
| Δ AEC before and 48 h NEC | −0.08 | 0.93 | 0.35 | 0.79 | 1.08 | −0.07 | 0.93 | 0.40 | 0.80 | 1.10 |
| Monocytes (%) | ||||||||||
| Δ % Monocyte before and day of NEC | 0.02 | 1.02 | 0.48 | 0.96 | 1.08 | 0.02 | 1.02 | 0.48 | 0.96 | 1.08 |
| Δ % Monocyte before and 24 h NEC | −0.01 | 0.99 | 0.69 | 0.93 | 1.05 | −0.01 | 0.99 | 0.71 | 0.93 | 1.05 |
| Δ % Monocyte before and 48 h NEC | −0.04 | 0.96 | 0.27 | 0.89 | 1.03 | −0.05 | 0.96 | 0.25 | 0.88 | 1.03 |
| Neutrophil (%) | ||||||||||
| Δ % Neutrophil before and day of NEC | 0.03 | 1.03 | 0.02 | 1.004 | 1.05 | 0.03 | 1.03 | 0.02 | 1.003 | 1.05 |
| Δ % Neutrophil before and 24 h NEC | 0.02 | 1.02 | 0.17 | 0.99 | 1.05 | 0.02 | 1.02 | 0.18 | 0.99 | 1.05 |
| Δ % Neutrophil before and 48 h NEC | 0.04 | 1.04 | 0.04 | 1.002 | 1.08 | 0.04 | 1.04 | 0.05 | 1.00 | 1.08 |
| Lymphocyte (%) | ||||||||||
| Δ % Lymphocyte before and day of NEC | −0.02 | 0.98 | 0.20 | 0.96 | 1.008 | −0.02 | 0.98 | 0.20 | 0.96 | 1.01 |
| Δ % Lymphocyte before and 24 h NEC | 0.001 | 1.001 | 0.95 | 0.97 | 1.04 | 0.001 | 1.00 | 0.99 | 0.97 | 1.04 |
| Δ % Lymphocyte before and 48 h NEC | 0.002 | 1.002 | 0.94 | 0.95 | 1.05 | 0.003 | 1.00 | 0.90 | 0.96 | 1.05 |
Adjusted models: models are adjusted for gestational age and birth weight; all values reported as OR (95% CI); ref: medical non-fulminant NEC; p value compares fulminant NEC and medical non-fulminant group. 48-h time point represents the data from alive infants between 24 and 48 h.
Statistically significant p < 0.05 values are in bold.
OR odds ratio, CI confidence interval.