Fig. 1.

Leucine restriction (LR) has effect on fat mass reduction. a–c Body weight, fat mass, and lean mass of mice fed with 0% LR (control) or 25% LR (left), 50% LR (middle), and 75% LR (right) diet for 8 weeks. d Body weight of mice fed with LR (control) or 50% LR diet over 12 weeks. e Weight of subcutaneous white adipose tissue (sWAT), epididymal white adipose tissue (eWAT), and brown adipose tissue (BAT) of mice fed with 0% LR (control) or 50% LR diet. Data are expressed as the mean ± SEM (n = 4–6 per group, as indicated), with individual data points. *p < 0.05