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. 2021 Mar 26;19:126. doi: 10.1186/s12967-021-02792-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — KEGG pathway enrichment analysis of PRDX1 co-expression genes and miRNA targets of PRDX1 in HCC. a Volcano plot showed the differential expression of genes related to PRDX1 in HCC and a Pearson correlation was used for the correlation analysis. Green: negatively correlated significant genes; red: positively correlated significant genes. b Top 50 positively and top 50 negatively correlated significant genes of PRDX1 were presented in the heat map. c The KEGG pathway enrichment of PRDX1 co-expression genes in HCC was analyzed using Gene Set Enrichment Analysis (GSEA). d The miRNA targets of PRDX1 in HCC. FDR false discovery rate