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. 2021 Mar 26;18:16. doi: 10.1186/s12989-021-00408-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 11 — T cell subtypes in the spleen following 30-day MWCNT exposure + 10 days recovery. a CD8⁺ cytotoxic T lymphocytes (CTL) as a percent of total T cells (CD3⁺ lymphocytes). Asterisks *** indicate significance at P < 0.001 compared to all other groups or * P < 0.05 compared to air control group. b Activated cytotoxic T lymphocytes expressing high levels of CD44 as a percent of total T cells. c CD4⁺ T helper cells as a percent of total T cells. Asterisk * indicate significance at P < 0.05 compared to all other groups. d Activated T helper cells expressing high CD44 as a percent of total T cells. Asterisks *** P < 0.001, ** P < 0.01 or *P < 0.05 compared to Air control group. e Ratio of CD4⁺ to CD8⁺ T cells. Asterisks *** indicate significance at P < 0.001 compared to all other groups or * P < 0.05 compared to air control group. All data expressed as mean ± SEM (n = 8)