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. 2021 Mar 26;18:16. doi: 10.1186/s12989-021-00408-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 12 — Changes in monocyte subpopulations and neutrophil populations in the spleen following 30-day MWCNT exposure + 10 days recovery to MWCNT. At multiple doses of particle exposure, splenic cell populations were assessed for changes using flow cytometry. Spleens were removed and disrupted to achieve single-cell suspensions for analysis. a Change in total monocyte populations (CD11b⁺ Ly6C^lo/hi), where a nonsignificant increase in the total monocyte population were observed. b Shows changes in the inflammatory monocyte populations with significant increases in iMono/M-MDSC (CD11b⁺ Ly6C^hi) for the highest 2 doses compared the low dose and the air control *** P < 0.001. c Shows changes in the resident monocyte populations with nonsignificant and significant decreases in rMono (CD11b⁺ Ly6C^lo) for all particle doses compared to the air control *** P < 0.001. d Neutrophil (PMN, CD11b⁺ Ly6G⁺) percent showed no significant changes across dose, but there was a nonsignificant increase in the 0.2 mg/m³ dose. Mono = total monocytes; iMono = inflammatory monocytes; M-MDSC = monocytic myeloid-derived suppressor cells; rMono = resident monocytes, and PMN = neutrophils. All data expressed as mean ± SEM (n = 8)