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. 2021 Mar 25;12:4. doi: 10.1186/s13227-021-00172-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Successional dental epithelium (SDE) expression in zebrafish and stickleback. In all panels, a dotted line demarcates the basalmost pharyngeal epithelial layer, which is made gray when missing from a particular section (e.g., when it is interrupted by an erupted tooth). a Expression of bmp6, bmpr1aa, cd34, gli1, igfbp5a, nfatc1, lgr4, lgr6, pitx2 was assayed by in situ hybridization (ISH) in zebrafish. Expression of all 9 genes was detected in the successional dental lamina (SDL—black arrowheads). b Expression of Bmp6, Bmpr1a, CD34, Gli1, Igfbp5a, Lgr4, Lgr6, Nfatc1b, and Pitx2 was assayed by ISH in stickleback. Expression of all nine genes was detected in the proposed “successional dental epithelium” (SDE) of stickleback. Black arrowheads mark the SDE. Bmpr1a and Gli1 were additionally expressed in the superficial oral epithelium surrounding erupted teeth (white arrowheads). Tooth germs are indicated with a black arrow. All scale bars = 20 μm