Table 1.
Characteristics of the study cohort
| CN (n = 91) | CI (n = 127) | p-value | |
|---|---|---|---|
| Demographic and clinical characteristics | |||
| Sex, female (%) | 64.4 | 53.9 | 0.12 |
| Age (years), mean ± SD | 68.53 ± 7.31 | 74 ± 6.6 | < 0.001 |
| Years of education (years), mean ± SD | 13.02 ± 2.54 | 12.26 ± 2.78 | 0.04 |
| CDR, mean ± SD | 0 | 0.59 ± 0.26 | < 0.001 |
| CDRSoB, mean ± SD | 0.01 ± 0.07 | 2.12 ± 2.14 | < 0.001 |
| MMSE, mean ± SD | 28.59 ± 1.25 | 25.29 ± 3.83 | < 0.001 |
| Biochemical measures | |||
| APOE ε4, n (%) | 18 (21.2) | 50 (43.5) | 0.001 |
| QAlb, mean ± SD | 5.45 ± 2.28 | 6.93 ± 3 | 0.002 |
| CSF AD biomarkers | < 0.001 | ||
| Aβ1–42, pg/ml, mean ± SD | 1030.62 ± 262.46 | 754.58 ± 287.32 | < 0.001 |
| Tau, pg/ml, mean ± SD | 301.09 ± 175.95 | 493.04 ± 308.79 | < 0.001 |
| p-tau181, pg/ml, mean ± SD | 57.74 ± 20.48 | 70.49 ± 29.77 | < 0.001 |
| Aβ1–42/Aβ1–40 | 0.07 ± 0.02 | 0.05 ± 0.02 | < 0.001 |
| MRI | |||
| Hippocampal volume | 0.0046 ± 46E-5 | 0.0041 ± 57E-5 | < 0.001 |
| Plasma biomarkers | |||
| NfL, pg/ml, mean ± SD | 17.61 ± 9.24 | 24.66 ± 11.66 | < 0.001 |
| p-tau181, pg/ml, mean ± SD | 9.58 ± 7.09 | 14.78 ± 9.69 | < 0.001 |