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Circulation CAFs. CAFs from primary tumor can intravasate into blood vessels even before CTCs appearing and are transported to target organ to modify the metastatic microenvironment into a hospitable location for colonization of tumor cells. CAFs can also be a part of CTC clusters and enhance the metastatic ability of tumor cells. Once arrived at metastasis loci, c-CAFs might prompt tumor cells to escape dormancy and initiate early growth
