Table 2.
MIC and MEC values to seven antifungal drugs against Scedosporium spp.
| Strains | MIC Parameters | Antifungal Drugs (mg/L) | ||||||
|---|---|---|---|---|---|---|---|---|
| AMB | ITR | VOR | POS | ANI * | CAS * | MICA * | ||
| S. boydii (n = 28) | GM | 1.52 | 0.34 | 0.15 | 0.16 | 0.53 | 0.44 | 0.19 |
| MIC 50 | 2 | 0.5 | 0.125 | 0.25 | 1 | 1 | 0.25 | |
| MIC 90 | 8 | 4 | 0.25 | 1 | 4 | 4 | 2 | |
| Range | 0.032–8 | 0.008–8 | 0.015–0.5 | 0.008–1 | 0.008–8 | 0.008–8 | 0.008–8 | |
| n (%) | 17 (60.7) | 5 (17.8) | 1 (3.5) | 0 (0) | 11(39.2) | 12(42.8) | 3 (10.7) | |
| S. apiospermum (n = 12) | GM | 2.52 | 1.41 | 0.35 | 0.44 | 1.69 | 1.20 | 0.66 |
| MIC 50 | 4 | 1 | 0.5 | 0.5 | 4 | 1 | 0.5 | |
| MIC 90 | 8 | 8 | 0.5 | 1 | 8 | 16 | 8 | |
| Range | 0.5–16 | 0.125–16 | 0.125–4 | 0.125–16 | 0.032–16 | 0.032–16 | 0.064–16 | |
| n (%) | 8 (66.6) | 5 (41.6) | 1 (8.3) | 1 (8.3) | 8 (66.6) | 5 (41.6) | 3 (25) | |
| S. angustum (n = 5) | GM | 2.30 | 1.15 | 0.28 | 0.43 | 2.30 | 2 | 0.32 |
| Range | 1–8 | 0.25–8 | 0.064–1 | 0.064–2 | 1–4 | 0.5–4 | 0.125–0.5 | |
| n (%) | 3 (60) | 2 (40) | 0 (0) | 1 (20) | 4 (80) | 4 (80) | 0 (0) | |
| S. aurantiacum (n = 2) | DMic 175378 | 16 | 2 | 0.5 | 1 | 8 | 16 | 8 |
| DMic 175588 | 8 | 4 | 0.5 | 1 | 4 | 8 | 8 | |
| n (%) | 2 (100) | 2 (100) | 0 (0) | 0 (0) | 2 (100) | 2 (100) | 2 (100) | |
| S. americanum sp. nov. (n = 2) | DMic 165285 | 8 | 1 | 0.5 | 1 | 1 | 2 | 0.5 |
| CBS 128.35 | 4 | 0.5 | 0.25 | 0.25 | 2 | 1 | 0.25 | |
| n (%) | 2 (100) | 0 (0) | 0 (0) | 0 (0) | 1 (50) | 1 (50) | 0 (0) | |
| S. dehoogii (n = 1) | DMic 01867 | 8 | 0.25 | 0.25 | 0.25 | 4 | 4 | 0.5 |
AMB: amphotericin B; ITR: itraconazole; VOR: voriconazole; POS: posaconazole; ANI: anidulafungin; CAS: caspofungin; MICA: micafungin. GM: geometric mean; MIC: minimal inhibitory concentration; MEC: minimal effective concentration; * For echinocandins reading was performed at 24 h of incubation and MEC value was considered; n/%: number and percentage of species that showed MIC/MEC values ≥2 mg/L.