TABLE 3.
Association between MAPT haplotypes and cortical LB counts
| Association With Middle Frontal LB Count |
Association With Superior Temporal LB Count |
Association With Inferior Parietal LB Count |
Association With Cingulate LB Count |
Association With Parahippocampal LB Count |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype | Frequency (%) | Regression Coefficient (95% CI) |
P Value | Regression Coefficient (95% CI) |
P Value | Regression Coefficient (95% CI) |
P Value | Regression Coefficient (95% CI) |
P Value | Regression Coefficient (95% CI) |
P Value |
| H1b | 16.5 | −0.08 (−0.28, 0.11) | 0.40 | 0.00 (−0.23, 0.22) | 0.97 | −0.05 (−0.24, 0.13) | 0.58 | −0.07 (−0.27, 0.13) | 0.52 | −0.10 (−0.34, 0.14) | 0.42 |
| H1c | 11.9 | −0.03 (−0.24, 0.17) | 0.72 | −0.15 (−0.38, 0.09) | 0.20 | −0.12 (−0.31, 0.07) | 0.21 | −0.05 (−0.26, 0.16) | 0.62 | −0.10 (−0.36, 0.15) | 0.38 |
| H1d | 7.3 | 0.07 (−0.21, 0.36) | 0.63 | 0.12 (−0.21, 0.45) | 0.50 | 0.13 (−0.14, 0.39) | 0.37 | 0.11 (−0.18, 0.41) | 0.47 | 0.09 (−0.27, 0.46) | 0.65 |
| H1e | 8.5 | −0.07 (−0.33, 0.18) | 0.58 | −0.13 (−0.43, 0.16) | 0.38 | −0.13 (−0.37, 0.11) | 0.31 | −0.12 (−0.39, 0.14) | 0.37 | −0.17 (−0.49, 0.14) | 0.27 |
| H1fa | 1.1 | −0.78 (−1.62, 0.07) | 0.078 | −0.40 (−1.38, 0.58) | 0.45 | −0.53 (−1.33, 0.26) | 0.21 | −0.47 (−1.35, 0.41) | 0.28 | — | — |
| H1g | 1.8 | 0.27 (−0.25, 0.78) | 0.33 | 0.01 (−0.59, 0.60) | 0.98 | 0.37 (−0.12, 0.85) | 0.16 | 0.21 (−0.33, 0.74) | 0.45 | 0.25 (−0.39, 0.90) | 0.46 |
| H1h | 3.9 | 0.05 (−0.34, 0.44) | 0.81 | 0.20 (−0.26, 0.65) | 0.40 | 0.21 (−0.15, 0.58) | 0.27 | 0.10 (−0.31, 0.51) | 0.63 | 0.06 (−0.42, 0.55) | 0.79 |
| H1i | 2.9 | 0.07 (−0.43, 0.57) | 0.73 | 0.11 (−0.47, 0.69) | 0.68 | 0.03 (−0.44, 0.50) | 0.84 | 0.07 (−0.46, 0.60) | 0.75 | 0.74 (0.13, 1.36) | 0.016 |
| H1j | 1.3 | −0.49 (1.32, 0.34) | 0.29 | −0.24 (−1.21, 0.72) | 0.62 | −0.23 (−1.91, 0.55) | 0.59 | −0.29 (−1.15, 0.58) | 0.55 | 0.13 (−0.86, 1.13) | 0.75 |
| H1ka | 1.2 | — | — | — | — | — | — | — | — | −0.26 (−1.27, 0.75) | 0.59 |
| H1l | 2.5 | −0.06 (−0.53, 0.40) | 0.80 | 0.21 (−0.33, 0.75) | 0.44 | 0.08 (−0.36, 0.51) | 0.73 | −0.12 (−0.61, 0.37) | 0.54 | 0.21 (−0.47, 0.88) | 0.55 |
| H1m | 1.9 | −0.27 (−0.79, 0.25) | 0.32 | −0.31 (−0.92, 0.29) | 0.32 | −0.20 (−0.69, 0.29) | 0.41 | −0.17 (−0.71, 0.37) | 0.54 | −0.15 (−0.82, 0.53) | 0.67 |
| H1o | 2.9 | −0.09 (−0.57, 0.39) | 0.72 | −0.29 (−0.85, 0.27) | 0.34 | −0.08 (−0.54, 0.37) | 0.73 | 0.00 (−0.50, 0.50) | 0.99 | −0.51 (−1.11, 0.09) | 0.11 |
| H1p | 1.2 | −0.15 (−0.89, 0.58) | 0.69 | −0.58 (−1.42, 0.27) | 0.19 | −0.51 (−1.20, 0.18) | 0.13 | −0.35 (−1.11, 0.41) | 0.37 | −0.41 (−1.33, 0.51) | 0.43 |
| H1q | 1.2 | 0.48 (−0.13, 1.08) | 0.11 | 0.69 (0.01, 1.38) | 0.041 | 0.42 (−0.15, 0.99) | 0.14 | 0.48 (−0.15, 1.11) | 0.12 | 0.46 (−0.30, 1.21) | 0.20 |
| H1r | 1.7 | 0.42 (−0.19, 1.03) | 0.14 | 0.10 (−0.61, 0.81) | 0.77 | 0.49 (−0.08, 1.07) | 0.068 | 0.23 (−0.41, 0.87) | 0.47 | 0.45 (−0.38, 1.29) | 0.24 |
| H1s | 1.5 | −0.27 (−0.79, 0.25) | 0.95 | −0.31 (−0.92, 0.29) | 0.74 | −0.20 (−0.69, 0.29) | 0.63 | −0.17 (−0.71, 0.37) | 0.58 | −0.15 (−0.82, 0.53) | 0.84 |
| H1u | 3.0 | −0.21 (−0.65, 0.23) | 0.38 | −0.30 (−0.82, 0.21) | 0.27 | −0.20 (−0.61, 0.22) | 0.37 | −0.01 (−0.47, 0.45) | 0.99 | −0.05 (−0.67, 0.57) | 0.94 |
| H1x | 1.2 | −0.10 (−0.81, 0.60) | 0.79 | 0.07 (−0.75, 0.89) | 0.83 | −0.22 (−0.88, 0.44) | 0.52 | −0.23 (−0.99, 0.53) | 0.54 | −0.31 (−1.22, 0.60) | 0.55 |
| H1y | 1.5 | −0.22 (−0.92, 0.47) | 0.42 | 0.18 (−0.63, 0.99) | 0.67 | −0.26 (−0.91, 0.40) | 0.30 | −0.39 (−1.11, 0.34) | 0.18 | 0.14 (−0.72, 0.99) | 0.66 |
| H1z | 1.1 | 0.63 (−0.14, 1.41) | 0.12 | 0.57 (−0.33, 1.47) | 0.21 | 0.35 (−0.38, 1.08) | 0.33 | 0.51 (−0.29, 1.32) | 0.23 | 0.50 (−0.49, 1.49) | 0.34 |
| H2 | 22.5 | 0.10 (−0.05, 0.26) | 0.19 | 0.12 (−0.06, 0.30) | 0.18 | 0.11 (−0.04, 0.25) | 0.15 | 0.12 (−0.04, 0.28) | 0.14 | 0.10 (−0.10, 0.29) | 0.33 |
P values result from score tests of association that were adjusted for age and sex, where haplotypes that occurred in <1% of LBD cases in a given association analysis were excluded from that analysis. Regression coefficients correspond to the change in the mean outcome measure (on the square root scale) for each additional copy of the given haplotype. P values ≤0.0024 were considered to be statistically significant after applying a Bonferroni correction for the 21 tests of association that were performed for each outcome.
Indicates a haplotype that was observed at an overall frequency of <1% in a particular analysis and was therefore excluded from that analysis; sample sizes utilized in different analyses varied because of varying missing LB count information in the different cortical regions. Associations between haplotypes and outcomes that had P values ≤0.05 are shown in bold.