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. 2020 Sep 22;16(3):433–439. doi: 10.4103/1673-5374.293129

Figure 2.

Figure 2

Diagrammatic representation of the main pathological mechanism in the penumbra leading to cell death by apoptosis.

[ ]: Concentration; e: extracellular; Glu: glucose; Glut: glutamate; Glut R: glutamate receptor; i: intracellular; RNS: reactive nitrogen species; ROS, reactive oxygen species; VGIC: voltage-gated ion channels. Adapted from López-Valdés et al. (2020).