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. 2020 Sep 22;16(3):510–511. doi: 10.4103/1673-5374.293147

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Copyright: © 2021 Neural Regeneration Research

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Possible role of transforming growth factor β1 (TGF-β1) in multiple sclerosis neuroinflammation and oligodendroglia maturation.

In an early demyelinating environment, glial TGF-β1 (yellow circles) might increase the blood-brain barrier (BBB) permeability, favoring the passage of peripheral immune cells, such as T cells, and promoting myelin damage and neuroinflammation. However, during the remyelination process, glial TGF-β1 could favor the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OL), which in turn will promote myelin regeneration. This figure was prepared based on the free online Servier Medical Art repository images (https://smart.servier.com/).