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. 2021 Feb 16;143(13):1287–1298. doi: 10.1161/CIRCULATIONAHA.120.047829

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© 2021 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 4. — Incidence-free KM survival curves within the holdout set for subpopulations defined by sex, and age groups. The top row shows the KM curves for subpopulations in age groups: <50 years, 50 to 65 years, and ≥65 years for men (left) and women (right). The bottom row shows the KM curves for the model-predicted (model M0 trained with ECG traces, age, and sex; DNN-ECG-AS) low-risk groups and high-risk groups for new-onset atrial fibrillation for each age group for men and women. It also reflects relative hazards between age groups. The horizontal dotted gray line represents incidence-free proportion of 50%, and vertical lines represent the median survival time for the respective curves. DNN indicates deep neural network; and KM, Kaplan-Meier.