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Synthesis of 5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one derivatives 58–62. Reagents and conditions: (a) substituted amine, EtOH, reflux, 12 h, 57–99%, (b) (i) 10% NaOH/MeOH (1:3), reflux 3 h, (ii) 2 N HCl, 56–96%, (c) 2-bromo-N-(3,4-dimethoxyphenyl)acetamide 26, Et3N, MeCN, reflux, 5 h, 50–90%.
