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. 2021 Mar 23;36(1):831–846. doi: 10.1080/14756366.2021.1900158

Table 2.

In vitro cell-based assay results of 9–20.

graphic file with name IENZ_A_1900158_ILG0002_C.jpg

Compound R1 R2 Recovery of ΔΨm (%) ATP Recovery (%) MTT
 ROS Inhibition (%)
Recovery (%) Viability (%)
7 (VH034)     78% 42% 28% 95% 97%
9 (VH057) OMe Me 30% ND ND ND ND
10 (VH058) OEt Me 52% 49% 45% 87% −177%
11 (VH059) OEt i-Bu 59% ND ND ND −234%
12 (VH060) OEt n-Bu 1% ND ND ND ND
13 (VH061) OMe graphic file with name IENZ_A_1900158_ILG0003_B.gif 66% 14% ND ND ND
14 (VH062) OMe graphic file with name IENZ_A_1900158_ILG0004_B.gif 77% 122% 92% 120% 136%
15 (VH063) OEt graphic file with name IENZ_A_1900158_ILG0005_B.gif 86% 31% 59% 139% −4%
16 (VH064) OMe graphic file with name IENZ_A_1900158_ILG0006_B.gif 74% 38% 32% 135% 112%
17 (VH065) graphic file with name IENZ_A_1900158_ILG0007_B.gif graphic file with name IENZ_A_1900158_ILG0008_B.gif 72% −105% ND ND ND
18 (VH066) graphic file with name IENZ_A_1900158_ILG0009_B.gif graphic file with name IENZ_A_1900158_ILG0010_B.gif 53% −18% ND ND ND
19 (VH067) graphic file with name IENZ_A_1900158_ILG0011_B.gif graphic file with name IENZ_A_1900158_ILG0012_B.gif 73% −77% ND ND ND
20 (VH068) graphic file with name IENZ_A_1900158_ILG0013_B.gif graphic file with name IENZ_A_1900158_ILG0014_B.gif 50% −55% ND ND ND
Piracetam     60% 127% 29% 132% 129%
CsA     55% −46% 61% 90% NDa

ND: Not determined.