Table 3.

In vitro assay results of compounds 27–47.

Compound	R2	R3	Recovery of ΔΨm	ATP recovery	MTT
					Recovery	Viability
27	H	3,4-difluorophenyl	73%	−15%	−4%	92%
28	H	2-(Piperidin-1-yl)ethyl	78%	−10%	−22%	71%
29	H	3-(Piperidin-1-yl)propyl	69%	−22%	−10%	89%
30	H	1-Methylpiperidin-4-yl	68%	60%	6%	98%
31	H	Benzyl	81%	59%	18%	109%
32	Methyl	Benzyl	83%	7%	8%	88%
33	Ethyl	Benzyl	86%	7%	35%	104%
34	H	4-Chlorobenzyl	82%	40%	20%	97%
35	H	4-Chlorophenyl	82%	38%	18%	107%
36	H	4-Methylbenzyl	82%	35%	2%	96%
37	Methyl	Methyl	45%	ND	ND	ND
38	Ethyl	Ethyl	65%	12%	5%	77%
39	n-Propyl	n-Propyl	79%	15%	26%	99%
40	n-Butyl	n-Butyl	80%	33%	32%	107%
41	H	n-Propyl	51%	ND	ND	ND
42	H	Isopropyl	51%	ND	ND	ND
43	H	n-Butyl	73%	1%	−27%	79%
44	4-Phenylpiperazin-1-yl		83%	63%	9%	97%
45	4-Benzylpiperazin-1-yl		78%	54%	−31%	113%
46	4-Phenylpiperidin-1-yl		82%	80%	28%	86%
47	4-Benzylpiperidin-1-yl		81%	86%	31%	94%
7			73%	42%	28%	95%

ND: Not determined.