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Minimum Inhibitory Concentration (µM) of 3-phenyl-1H-indazole derivatives.
| ID | R | C. albicans | C. glabrata | C. glabrata 1 |
|---|---|---|---|---|
| 10a | H | 100 | 150 | 100 |
| 10b | CO2H | 200 | 100 | – |
| 10c | CO2Me | 75 | 100 | 200 |
| 10d | CONH2 | 150 | 150 | 100 |
| 10e | CONHMe | 150 | 100 | 100 |
| 10f | CONMe2 | 150 | 75 | 75 |
| 10g | CONEt2 | 75 | 100 | 75 |
| 10h | CONC4H8 | 100 | 100 | 150 |
| 10i | CONC5H10 | 75 | 100 | 125 |
| Fluconazole | 50 | – | 50 | |
| Miconazole | <50 | <50 | – |
1 Miconazole resistant; (–) inactive.
