Table 1.
Clinical manifestations in different animal models of filovirus infections [30].
| Manifestation | Immuno-Competent Mouse | Immuno-Compromised Mouse | Guinea Pig | Syrian Hamster | Ferret | NHP | Human |
|---|---|---|---|---|---|---|---|
| Lymphopenia | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Liver damage | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Thrombocytopenia | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Coagulopathy | No | Unknown | Yes | Yes | Yes | Yes | Yes |
| Cytokine Storm | Yes | Yes | Unknown | Yes | Unknown | Yes | Yes |
| Rash | No | No | No | Yes | Yes | Yes | Yes |
| Hemorrhage signs | No | Yes | Unknown | Yes | Yes | Yes | Yes |
NHP: Non-human primates; Virus is host-adapted for mouse, guinea pig, and Syrian hamster and wild-type for ferret, NHP, and Human.