Table 2.
Geometric mean, 95% confidence interval (CI), minimum and maximum of particle count, mode size, total protein concentration, and EV-associated protein marker abundance quantified in EVs isolated in the morning and afternoon on study day 1 from serum of healthy volunteers (n = 10).
| Particle Count (Particles/mL) | Mode Size (nm) | |||
|---|---|---|---|---|
| AM | PM | AM | PM | |
| Mean | 2.82 × 1011 | 2.40 × 1011 | 83.0 | 84.7 |
| 95% CI Lower | 1.07 × 1011 | 1.12 × 1011 | 75.2 | 80.5 |
| 95% CI Upper | 7.24 × 1011 | 5.13 × 1011 | 91.8 | 89.1 |
| Minimum | 3.02 × 1010 | 4.37 × 1010 | 64.9 | 76.0 |
| Maximum | 1.26 × 1012 | 1.02 × 1012 | 99.3 | 92.9 |
| Protein Concentration (µg/mL) | ASGR1 Response | |||
| AM | PM | AM | PM | |
| Mean | 347.5 | 219.8 | 147.9 | 331.9 |
| 95% CI Lower | 104.2 | 90.8 | 76.6 | 115.9 |
| 95% CI Upper | 1161.5 | 533.3 | 286.4 | 952.8 |
| Minimum | 26.4 | 27.9 | 21.2 | 31.2 |
| Maximum | 2799.0 | 1345.9 | 421.7 | 6622.2 |
| CD9 Response | CD63 Response | |||
| AM | PM | AM | PM | |
| Mean | 57.2 | 55.9 | 28.2 | 86.9 |
| 95% CI Lower | 38.6 | 39.8 | 5.2 | 12.5 |
| 95% CI Upper | 84.5 | 79.6 | 153.5 | 605.3 |
| Minimum | 28.2 | 31.0 | 2.6 | 1.3 |
| Maximum | 140.0 | 183.7 | 1158.8 | 4954.5 |
| CD81 Response | TSG101 Response | |||
| AM | PM | AM | PM | |
| Mean | 120.0 | 94.2 | 9.11 | 11.6 |
| 95% CI Lower | 77.1 | 61.7 | −0.73 | 6.6 |
| 95% CI Upper | 187.1 | 143.9 | 15.5 | 20.4 |
| Minimum | 56.6 | 24.6 | 2.9 | 4.6 |
| Maximum | 334.2 | 264.9 | 40.9 | 35.8 |