. 2021 Feb 24;10(3):485. doi: 10.3390/cells10030485

Table 3.

Geometric mean and 95% confidence interval (CI) of particle count, mode size, total protein concentration, and EV-associated protein marker abundance quantified in EVs isolated from serum of healthy volunteers (n = 10) in fed state and after an overnight fast. Statistical analysis performed using paired t-tests. ns: not significant; * p ≤ 0.05.

	Particle Count (Particles/mL)				Mode Size (nm)
	Fed	Fast	Difference	p	Fed	Fast	Difference	p
Mean	2.82 × 10¹¹	2.09 × 10¹¹	ns	0.193	83.0	92.0	ns	0.093
95% CI Lower	1.07 × 10¹¹	6.61 × 10¹⁰			75.2	80.4
95% CI Upper	7.24 × 10¹¹	6.46 × 10¹¹			91.8	105.4
	Protein Concentration (µg/mL)				ASGR1 Response
	Fed	Fast	Difference	p	Fed	Fast	Difference	p
Mean	347.5	822.2	ns	0.1602	147.9	168.7	ns	0.732
95% CI Lower	104.2	619.4			76.6	99.1
95% CI Upper	1161.5	1094.0			286.4	287.7
	CD9 Response				CD63 Response
	Fed	Fast	Difference	p	Fed	Fast	Difference	p
Mean	57.2	90.6	*	0.018	28.2	41.5	ns	0.680
95% CI Lower	38.6	65.0			5.2	5.3
95% CI Upper	84.5	126.2			153.5	322.9
	CD81 Response				TSG101 Response
	Fed	Fast	Difference	p	Fed	Fast	Difference	p
Mean	120.0	117.2	ns	0.886	9.1	7.9	ns	0.668
95% CI Lower	77.1	76.6			5.4	4.4
95% CI Upper	187.1	179.5			15.5	14.1